When considering how frequently to schedule rejuran i injections, most dermatologists recommend spacing treatments 4 to 6 weeks apart initially. This interval aligns with the skin’s natural 28-day cellular turnover cycle, allowing polynucleotides to fully integrate with damaged tissues. A 2021 clinical trial published in the *Journal of Aesthetic Dermatology* observed that patients who received three sessions at 5-week intervals saw 42% greater collagen density improvement compared to those with irregular scheduling.
The treatment’s longevity plays a key role in determining maintenance needs. While individual results vary based on factors like age and skin condition, data from Seoul National University Hospital shows 70% of users maintain optimal results for 6-9 months after their initial series. One notable case involved a 38-year-old patient with acne scarring who underwent four monthly sessions followed by biannual touch-ups – her before-and-after photos demonstrated 80% scar texture improvement over 18 months.
But why can’t you get injections weekly? The answer lies in Rejuran I’s mechanism of action. Its polynucleotide (PN) formulation requires time to stimulate fibroblast activity and rebuild extracellular matrix structures. Over-treating before completing this biological process (typically 3-4 weeks) could reduce efficacy by 30-50%, according to manufacturer studies. Aesthetic clinics like Singapore’s Allure Skin Centre typically enforce mandatory 28-day gaps between appointments to protect patient outcomes.
For specific concerns, timelines adjust accordingly. Melasma patients might benefit from combining Rejuran I with quarterly Pico laser treatments, while those addressing surgical scars could require monthly injections for 5-6 months. Dr. Emily Cho from Beverly Hills Skin Group notes: “In my practice, 60% of clients doing preventative aging care opt for quarterly maintenance after their first three loading doses – this keeps skin rebound rates below 15% annually.”
Budget considerations also influence frequency. At an average cost of $500-$800 per session in major U.S. cities, many patients stagger treatments across 6-month periods. However, clinics in Malaysia and Thailand report 40% higher compliance rates due to prices being nearly half those in Western markets. The key is consistency – skipping more than two maintenance sessions annually could diminish cumulative benefits by up to 35%.
Side effect risks (occurring in less than 5% of cases according to FDA reports) also dictate timing. Though generally safe, practitioners insist on waiting at least 4 weeks between sessions to monitor for rare hypersensitivity reactions. This precaution proved crucial in a 2022 Seoul case where a patient developed temporary erythema after her second injection – the mandated break allowed proper healing before continuing treatment.
Ultimately, your ideal schedule depends on cellular response rates measured through hydration tests and VISIA complexion analysis. New York dermatologist Dr. Rachel Lin uses AI-powered skin mapping to predict optimal intervals, claiming this method improves patient satisfaction scores by 22% compared to standard protocols. Whether you’re targeting wrinkles or post-inflammatory erythema, remember – Rejuran I works cumulatively, meaning patience with the process yields better long-term rewards than rushing treatments.